InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ndor1

Summary

InnateDB Protein

IDBP-251960.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndor1

Protein Name

NADPH dependent diflavin oxidoreductase 1

Synonyms

4930447P04Rik; Ndor; NR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109989

InnateDB Gene

IDBG-144568 (Ndor1)

Protein Structure

UniProt Annotation

Function

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. {ECO:0000255HAMAP-Rule:MF_03178}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000255HAMAP-Rule:MF_03178}. Note=Concentrated in perinuclear structure. {ECO:0000255HAMAP-Rule:MF_03178}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003958	NADPH-hemoprotein reductase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0008219	cell death
GO:0016226	iron-sulfur cluster assembly
GO:0036245	cellular response to menadione
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0045111	intermediate filament cytoskeleton
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1926047

InterPro

IPR001094 Flavodoxin
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR003097 FAD-binding, type 1
IPR008254 Flavodoxin/nitric oxide synthase
IPR017938 Riboflavin synthase-like beta-barrel
IPR029039 Flavoprotein-like

PFAM

PF00175
PF00667
PF00258

PRINTS

PR00369
PR00371

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2AI05