InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cflar

Summary

InnateDB Protein

IDBP-252044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cflar

Protein Name

CASP8 and FADD-like apoptosis regulator

Synonyms

2310024N18Rik; A430105C05Rik; c-Flip; Cash; Casper; CLARP; ENSMUSG00000072980; FLAME; FLAME-1; Flip; Gm9845; I-FLICE; MRIT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109952

InnateDB Gene

IDBG-157342 (Cflar)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1336166

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001875 Death effector domain
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF01335
PF00656

PRINTS

PR00376

PIRSF

SMART

SM00031
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt