Version 5.4
Mus musculus Protein: Stradb
Summary
InnateDB Protein IDBP-252062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stradb
Protein Name STE20-related kinase adaptor beta
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000109935
InnateDB Gene IDBG-157650 (Stradb)
Protein Structure
UniProt Annotation
Function Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000902 cell morphogenesis
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0007010 cytoskeleton organization
GO:0007049 cell cycle
GO:0007254 JNK cascade
GO:0032147 activation of protein kinase activity
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2144047
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K4T3
PhosphoSite PhosphoSite-Q8K4T3
TrEMBL
UniProt Splice Variant
Entrez Gene 227154
UniGene Mm.286006
RefSeq
MGI ID
MGI Symbol Stradb
OMIM
CCDS
HPRD
IMGT
EMBL AB057666 AB057667 AK046790 AK080096 AK086974 AK140272 AK146079 BC060956
GenPept AAH60956 BAB68235 BAB68236 BAC32870 BAC37825 BAC39775 BAE24309 BAE26883

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca