Version 5.4
Mus musculus Protein: Clic3
Summary
InnateDB Protein IDBP-252144.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clic3
Protein Name chloride intracellular channel 3
Synonyms 2300003G24Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000109904
InnateDB Gene IDBG-145869 (Clic3)
Protein Structure
UniProt Annotation
Function Can insert into membranes and form chloride ion channels. May participate in cellular growth control (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0006821 chloride transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1916704
InterPro IPR002946 Intracellular chloride channel
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold
PFAM PF13098
PF13192
PF13462
PF13905
PRINTS PR01263
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D7P7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 69454
UniGene
RefSeq NP_081361
MGI ID
MGI Symbol Clic3
OMIM
CCDS CCDS15774
HPRD
IMGT
EMBL AK009020
GenPept BAB26030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca