Version 5.4
Mus musculus Gene: Clic3
Summary
InnateDB Gene IDBG-145869.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clic3
Gene Name chloride intracellular channel 3
Synonyms 2300003G24Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000015093
Encoded Proteins
IDBP-145871
chloride intracellular channel 3
IDBP-252144
chloride intracellular channel 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169583:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:25456838-25458776
Strand Forward strand
Band A3
Transcripts
ENSMUST00000102918 ENSMUSP00000099982
ENSMUST00000114265 ENSMUSP00000109904
ENSMUST00000140022
ENSMUST00000142006
ENSMUST00000132311
ENSMUST00000143862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0006821 chloride transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169583
View Gene Order
ENSBTAG00000015085
Not yet available
Cross-References
SwissProt Q9D7P7
TrEMBL
UniProt Splice Variant
Entrez Gene 69454
UniGene
RefSeq NM_027085 XM_006498296
OMIM
CCDS CCDS15774
HPRD
IMGT
MGI ID MGI:1916704
MGI Symbol Clic3
EMBL AK009020
GenPept BAB26030
RNA Seq Atlas 69454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca