InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smyd1

Summary

InnateDB Protein

IDBP-252280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smyd1

Protein Name

SET and MYND domain containing 1

Synonyms

4632404M21Rik; Bop; C78565; Zmynd18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109824

InnateDB Gene

IDBG-155362 (Smyd1)

Protein Structure

UniProt Annotation

Function

Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. {ECO:0000269PubMed:11923873, ECO:0000269PubMed:20943667}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11923873}. Nucleus {ECO:0000269PubMed:11923873}.

Disease Associations

Tissue Specificity

Expressed in cardiac and skeletal muscle, lymphocytes and thymus. {ECO:0000269PubMed:11923873, ECO:0000269PubMed:9013956}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0007507	heart development
GO:0010831	positive regulation of myotube differentiation
GO:0034968	histone lysine methylation
GO:0035914	skeletal muscle cell differentiation
GO:0045663	positive regulation of myoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated