InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nrp2

Summary

InnateDB Protein

IDBP-252337.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrp2

Protein Name

neuropilin 2

Synonyms

1110048P06Rik; Np-2; Np2; Npn-2; Npn2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109794

InnateDB Gene

IDBG-160044 (Nrp2)

Protein Structure

UniProt Annotation

Function

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in developing CNS, PNS and in some nonneural tissues including limb buds, developing bones, muscles, intestinal epithelium, kidney, lung and submandibular gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017154	semaphorin receptor activity
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001755	neural crest cell migration
GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007507	heart development
GO:0021675	nerve development
GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0048846	axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0061549	sympathetic ganglion development
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon

Protein Structure and Domains

PDB ID

MGI:1100492

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000859 CUB domain
IPR000998 MAM domain
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR014648 Neuropilin
IPR022579 Neuropilin-1, C-terminal

PFAM

PF00754
PF00431
PF00629
PF11980

PRINTS

PR00020

PIRSF

PIRSF036960

SMART

SM00231
SM00042
SM00137

TIGRFAMs

Post-translational Modifications

Modification

Cross-References