InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nrp2

Summary

InnateDB Gene

IDBG-160044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrp2

Gene Name

neuropilin 2

Synonyms

1110048P06Rik; Np-2; Np2; Npn-2; Npn2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025969

Encoded Proteins

IDBP-160046

neuropilin 2

IDBP-160048

neuropilin 2

IDBP-160050

neuropilin 2

IDBP-160052

neuropilin 2

IDBP-252337

neuropilin 2

IDBP-252339

neuropilin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118257:
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:62703285-62818695

Strand

Forward strand

Band

Transcripts

ENSMUST00000102822	ENSMUSP00000099886
ENSMUST00000027112	ENSMUSP00000027112
ENSMUST00000063594	ENSMUSP00000069379
ENSMUST00000075144	ENSMUSP00000074642
ENSMUST00000114157	ENSMUSP00000109794
ENSMUST00000114155	ENSMUSP00000109792
ENSMUST00000126344

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017154	semaphorin receptor activity
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001755	neural crest cell migration
GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007507	heart development
GO:0021675	nerve development
GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0048846	axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0061549	sympathetic ganglion development
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance