InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nacc2

Summary

InnateDB Protein

IDBP-252353.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nacc2

Protein Name

nucleus accumbens associated 2, BEN and BTB (POZ) domain containing

Synonyms

0610020I02Rik; AI448087; Btbd14a; C030048H19Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109796

InnateDB Gene

IDBG-147801 (Nacc2)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Note=Predominantly associated with chromatin. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010608	posttranscriptional regulation of gene expression
GO:0016575	histone deacetylation
GO:0034629	cellular protein complex localization
GO:1900477	negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage