InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agpat1

Summary

InnateDB Protein

IDBP-252398.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agpat1

Protein Name

1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)

Synonyms

1-AGP; 1-AGPAT; AW047140;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109776

InnateDB Gene

IDBG-172282 (Agpat1)

Protein Structure

UniProt Annotation

Function

Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:15367102}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0001819	positive regulation of cytokine production
GO:0006654	phosphatidic acid biosynthetic process
GO:0008152	metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0016024	CDP-diacylglycerol biosynthetic process