Version 5.4
Mus musculus Gene: Agpat1
Summary
InnateDB Gene IDBG-172282.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agpat1
Gene Name 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
Synonyms 1-AGP; 1-AGPAT; AW047140
Species Mus musculus
Ensembl Gene ENSMUSG00000034254
Encoded Proteins
IDBP-172284
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-252398
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-627456
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-627458
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-627459
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-627461
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
IDBP-627463
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204310:
This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34604262-34613449
Strand Forward strand
Band B1
Transcripts
ENSMUST00000037489 ENSMUSP00000048573
ENSMUST00000114140 ENSMUSP00000109776
ENSMUST00000174041 ENSMUSP00000133441
ENSMUST00000173242 ENSMUSP00000134242
ENSMUST00000173973 ENSMUSP00000133947
ENSMUST00000174228 ENSMUSP00000133876
ENSMUST00000174595 ENSMUSP00000134358
ENSMUST00000173146
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0006654 phosphatidic acid biosynthetic process
GO:0008152 metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0016024 CDP-diacylglycerol biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000204310
View Gene Order
ENSBTAG00000004442
Not yet available
Pathways
NETPATH
REACTOME
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_231395
ChREBP activates metabolic gene expression pathway
REACT_237947
Triglyceride Biosynthesis pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188640
Synthesis of PA pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
mmu00561
Glycerolipid metabolism pathway
mmu04975
Fat digestion and absorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120906
Synthesis of PA pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_2122
ChREBP activates metabolic gene expression pathway
REACT_1505
Integration of energy metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_211382
Synthesis of PA pathway
REACT_202421
Glycerophospholipid biosynthesis pathway
REACT_217101
Integration of energy metabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_209849
Triglyceride Biosynthesis pathway
REACT_219139
Metabolism pathway
REACT_218329
Phospholipid metabolism pathway
REACT_226051
ChREBP activates metabolic gene expression pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa00561
Glycerolipid metabolism pathway
hsa04975
Fat digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.8684
RefSeq NM_001163379 NM_018862 XM_006524647 XM_006524648 XM_006525424 XM_006525425 XM_006536674 XM_006537405
OMIM
CCDS CCDS37590
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca