InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ikbkg

Summary

InnateDB Protein

IDBP-252412.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ikbkg

Protein Name

inhibitor of kappaB kinase gamma

Synonyms

1110037D23Rik; AI848108; AI851264; AW124339; IKK[g]; NEMO;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109764

InnateDB Gene

IDBG-156458 (Ikbkg)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 356 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	95 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	356 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0019904	protein domain specific binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001782	B cell homeostasis
GO:0006974	cellular response to DNA damage stimulus
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0016310	phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0008385	IkappaB kinase complex

Protein Structure and Domains

PDB ID

MGI:1338074

InterPro

IPR009068 S15/NS1, RNA-binding
IPR021063 NF-kappa-B essential modulator NEMO, N-terminal

PFAM

PF11577

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q8VC91

UniProt Splice Variant

Entrez Gene

16151

UniGene

Mm.12967

RefSeq

MGI ID

MGI Symbol

Ikbkg

OMIM

CCDS

CCDS30233

HPRD

IMGT

EMBL

AK037020 AL669976 AL807376 BC021431 CH466650

GenPept

AAH21431 BAC29672 EDL29809