Version 5.4
| Mus musculus Gene: Ikbkg | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-156458.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Ikbkg | ||||||||||||||||||||||
| Gene Name | inhibitor of kappaB kinase gamma | ||||||||||||||||||||||
| Synonyms | 1110037D23Rik; AI848108; AI851264; AW124339; IKK[g]; NEMO | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000004221 | ||||||||||||||||||||||
| Encoded Proteins |
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of kappaB kinase gamma
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome X:74393290-74453854 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | A7.3 | ||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 356 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream TCR signaling pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
MyD88 cascade initiated on plasma membrane pathway
FCERI mediated NF-kB activation pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
activated TAK1 mediates p38 MAPK activation pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Activation of NF-kappaB in B cells pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
NOD1/2 Signaling Pathway pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
RIP-mediated NFkB activation via ZBP1 pathway
Adaptive Immune System pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
Interleukin-1 signaling pathway
MyD88-independent cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
TCR signaling pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
IRAK1 recruits IKK complex pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
MAPK signaling pathway pathway
Small cell lung cancer pathway
Adipocytokine signaling pathway pathway
Apoptosis pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Primary immunodeficiency pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
TNFR1 signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
NOD1/2 Signaling Pathway pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88-independent cascade pathway
Cytosolic sensors of pathogen-associated DNA pathway
activated TAK1 mediates p38 MAPK activation pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
IKK complex recruitment mediated by RIP1 pathway
Cytokine Signaling in Immune system pathway
Downstream TCR signaling pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Immune System pathway
MAP kinase activation in TLR cascade pathway
Signaling by the B Cell Receptor (BCR) pathway
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated NF-kB activation pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
FCERI mediated NF-kB activation pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
Adaptive Immune System pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Activation of NF-kappaB in B cells pathway
MyD88 dependent cascade initiated on endosome pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Innate Immune System pathway
Interleukin-1 signaling pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
RIP-mediated NFkB activation via ZBP1 pathway
Signaling by Interleukins pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
IRAK1 recruits IKK complex pathway
MyD88 cascade initiated on plasma membrane pathway
TCR signaling pathway
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| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | O88522 | ||||||||||||||||||||||
| TrEMBL | A3KG39 A3KG40 A3KG41 A3KG44 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 16151 | ||||||||||||||||||||||
| UniGene | Mm.12967 | ||||||||||||||||||||||
| RefSeq | NM_010547 NM_001136067 NM_001161421 NM_001161422 NM_001161423 NM_001161424 NM_178590 XM_006527847 XM_006527848 XM_006527849 XM_006527850 XM_006527851 XM_006527852 XM_006527853 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS41023 CCDS30233 CCDS53108 CCDS53109 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:1338074 | ||||||||||||||||||||||
| MGI Symbol | Ikbkg | ||||||||||||||||||||||
| EMBL | AF069542 AF326207 AF513109 AK154095 AL669976 AL807376 CH466650 | ||||||||||||||||||||||
| GenPept | AAC40153 AAK69186 AAP47160 BAE32372 CAM45971 EDL29810 | ||||||||||||||||||||||
| RNA Seq Atlas | 16151 | ||||||||||||||||||||||