InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ikbkg

Summary

InnateDB Protein

IDBP-252414.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ikbkg

Protein Name

inhibitor of kappaB kinase gamma

Synonyms

1110037D23Rik; AI848108; AI851264; AW124339; IKK[g]; NEMO;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109763

InnateDB Gene

IDBG-156458 (Ikbkg)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. {ECO:0000269PubMed:9927690}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 356 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	95 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	356 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001782	B cell homeostasis
GO:0006351	transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051092	positive regulation of NF-kappaB transcription factor activity