InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adam23

Summary

InnateDB Protein

IDBP-252430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adam23

Protein Name

a disintegrin and metallopeptidase domain 23

Synonyms

AW046396; MDC3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109742

InnateDB Gene

IDBG-160540 (Adam23)

Protein Structure

UniProt Annotation

Function

May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform Gamma: Secreted.

Disease Associations

Tissue Specificity

Brain specific. {ECO:0000269PubMed:10433968}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007155	cell adhesion

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1345162

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt