Version 5.4
Mus musculus Gene: Adam23
Summary
InnateDB Gene IDBG-160540.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adam23
Gene Name a disintegrin and metallopeptidase domain 23
Synonyms AW046396; MDC3
Species Mus musculus
Ensembl Gene ENSMUSG00000025964
Encoded Proteins
IDBP-160542
a disintegrin and metallopeptidase domain 23
IDBP-252430
a disintegrin and metallopeptidase domain 23
IDBP-789822
a disintegrin and metallopeptidase domain 23
IDBP-789821
a disintegrin and metallopeptidase domain 23
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114948:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. [provided by RefSeq, Jul 2008]
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:63445891-63596276
Strand Forward strand
Band C2
Transcripts
ENSMUST00000087374 ENSMUSP00000084633
ENSMUST00000097717
ENSMUST00000114107 ENSMUSP00000109742
ENSMUST00000114103 ENSMUSP00000139862
ENSMUST00000114101
ENSMUST00000146403
ENSMUST00000134704
ENSMUST00000141545
ENSMUST00000182642 ENSMUSP00000138362
ENSMUST00000190658
ENSMUST00000185616
ENSMUST00000187844
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007155 cell adhesion
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114948
View Gene Order
ENSBTAG00000019694
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.124892 Mm.396826
RefSeq NM_001177600 NM_011780 XM_006495969 XM_006495970 XM_006495971
OMIM
CCDS CCDS14999 CCDS48279
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca