Version 5.4
Mus musculus Protein: Cpeb2
Summary
InnateDB Protein IDBP-252558.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpeb2
Protein Name cytoplasmic polyadenylation element binding protein 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000109699
InnateDB Gene IDBG-160824 (Cpeb2)
Protein Structure
UniProt Annotation
Function May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12672660}.
Disease Associations
Tissue Specificity Expressed in embryo, cerebellum, salivary gland, thymus, heart, liver, lung, spleen, kidney, intestine, ovary and round spermatids. Weakly expressed in granular cells of dentate gyrus and the pyramidal cells of CA3 and CA1 of the hippocampus. {ECO:0000269PubMed:12672660, ECO:0000269PubMed:12871996}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000900 translation repressor activity, nucleic acid binding
GO:0003676 nucleic acid binding
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0008187 poly-pyrimidine tract binding
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0043022 ribosome binding
GO:0043023 ribosomal large subunit binding
GO:0043024 ribosomal small subunit binding
Biological Process
GO:0032869 cellular response to insulin stimulus
GO:0033125 negative regulation of GTP catabolic process
GO:0034260 negative regulation of GTPase activity
GO:0034599 cellular response to oxidative stress
GO:0045900 negative regulation of translational elongation
GO:0071243 cellular response to arsenic-containing substance
GO:0071456 cellular response to hypoxia
GO:1900248 negative regulation of cytoplasmic translational elongation
GO:2000766 negative regulation of cytoplasmic translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005844 polysome
GO:1990124 messenger ribonucleoprotein complex
Protein Structure and Domains
PDB ID MGI:2442640
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q812E0
PhosphoSite PhosphoSite-Q812E0
TrEMBL
UniProt Splice Variant
Entrez Gene 231207
UniGene Mm.7233
RefSeq
MGI ID
MGI Symbol Cpeb2
OMIM
CCDS
HPRD
IMGT
EMBL AB100307 BC107349 BC107350
GenPept AAI07350 AAI07351 BAC57076

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca