InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itsn1

Summary

InnateDB Protein

IDBP-252665.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Itsn1

Protein Name

intersectin 1 (SH3 domain protein 1A)

Synonyms

AA517634; AA545208; AI316805; AI839402; AI848451; Ehsh1; Ese1; Itsn; Sh3p17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109629

InnateDB Gene

IDBG-176668 (Itsn1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019209	kinase activator activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0042327	positive regulation of phosphorylation
GO:0043524	negative regulation of neuron apoptotic process
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0030027	lamellipodium
GO:0030139	endocytic vesicle

Protein Structure and Domains

PDB ID

MGI:1338069

InterPro

IPR000261 EPS15 homology (EH)
IPR001452 SH3 domain
IPR002048 EF-hand domain
IPR011511 Variant SH3 domain

PFAM

PF00018
PF14604
PF00036
PF13202
PF13405
PF07653

PRINTS

PR00452

PIRSF

SMART

SM00027
SM00326
SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q8CJ54

UniProt Splice Variant

Entrez Gene

16443

UniGene

Mm.40546

RefSeq

XP_006522999

MGI ID

MGI Symbol

Itsn1

OMIM

CCDS

HPRD

IMGT

EMBL

AC126053 AC131691 AC134837 AF498311

GenPept

AAN32914