InnateDB Protein
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IDBP-252746.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Suv420h1
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Protein Name
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suppressor of variegation 4-20 homolog 1 (Drosophila)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000109605
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InnateDB Gene
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IDBG-128370 (Suv420h1)
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Protein Structure
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Function |
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. {ECO:0000269PubMed:15145825, ECO:0000269PubMed:23720823}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:15145825}. Chromosome {ECO:0000269PubMed:15145825}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0018024
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histone-lysine N-methyltransferase activity
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GO:0042799
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histone methyltransferase activity (H4-K20 specific)
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Biological Process |
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Cellular Component |
GO:0000780
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condensed nuclear chromosome, centromeric region
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PDB ID |
MGI:2444557
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InterPro |
IPR001214
SET domain
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PFAM |
PF00856
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PRINTS |
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PIRSF |
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SMART |
SM00317
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TIGRFAMs |
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Modification |
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SwissProt |
Q3U8K7
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PhosphoSite |
PhosphoSite-Q3U8K7
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TrEMBL |
H3BKZ5
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UniProt Splice Variant |
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Entrez Gene |
225888
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UniGene |
Mm.472360
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RefSeq |
NP_001161359
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MGI ID |
4BUP
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MGI Symbol |
Suv420h1
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OMIM |
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CCDS |
CCDS50343
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HPRD |
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IMGT |
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EMBL |
AC132452
AK036880
AK054093
AK082660
AK083227
AK087267
AK139255
AK152179
AY555192
BC011214
BC075709
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GenPept |
AAH11214
AAH75709
AAT00539
BAC29617
BAC35652
BAC38565
BAC38817
BAC39834
BAE23934
BAE31010
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