InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcne2

Summary

InnateDB Protein

IDBP-252759.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcne2

Protein Name

potassium voltage-gated channel, Isk-related subfamily, gene 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109604

InnateDB Gene

IDBG-177527 (Kcne2)

Protein Structure

UniProt Annotation

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KCLQT1 and elicit a voltage-independent current (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding
GO:0015459	potassium channel regulator activity
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding
GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Biological Process

GO:0006811	ion transport
GO:0007568	aging
GO:0010107	potassium ion import
GO:0034613	cellular protein localization
GO:0035690	cellular response to drug
GO:0043586	tongue development
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0071435	potassium ion export
GO:0071805	potassium ion transmembrane transport
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086011	membrane repolarization during action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:1901800	positive regulation of proteasomal protein catabolic process
GO:1901979	regulation of inward rectifier potassium channel activity
GO:1902159	regulation of cyclic nucleotide-gated ion channel activity
GO:1902259	regulation of delayed rectifier potassium channel activity