InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wdr5

Summary

InnateDB Protein

IDBP-252787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wdr5

Protein Name

WD repeat domain 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109585

InnateDB Gene

IDBG-151154 (Wdr5)

Protein Structure

UniProt Annotation

Function

Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15860628}.

Disease Associations

Tissue Specificity

Expressed in liver (at protein level). Detected in brain, testis and kidney. {ECO:0000269PubMed:15860628}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 124 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	124 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0043995	histone acetyltransferase activity (H4-K5 specific)
GO:0043996	histone acetyltransferase activity (H4-K8 specific)
GO:0046972	histone acetyltransferase activity (H4-K16 specific)

Biological Process

GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0034968	histone lysine methylation
GO:0043966	histone H3 acetylation
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043984	histone H4-K16 acetylation
GO:0045722	positive regulation of gluconeogenesis
GO:0051568	histone H3-K4 methylation

Cellular Component

GO:0000123	histone acetyltransferase complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0035097	histone methyltransferase complex
GO:0048188	Set1C/COMPASS complex
GO:0071339	MLL1 complex

Protein Structure and Domains

PDB ID

MGI:2155884

InterPro

IPR001680 WD40 repeat
IPR013979 Translation initiation factor, beta propellor-like domain
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF08662

PRINTS

PR00320

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt