Version 5.4
Mus musculus Gene: Wdr5
Summary
InnateDB Gene IDBG-151154.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr5
Gene Name WD repeat domain 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026917
Encoded Proteins
IDBP-252787
WD repeat domain 5
IDBP-534237
WD repeat domain 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196363:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:27515157-27536535
Strand Forward strand
Band A3
Transcripts
ENSMUST00000113952 ENSMUSP00000109585
ENSMUST00000144315
ENSMUST00000140396 ENSMUSP00000121654
ENSMUST00000125088
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 124 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 124 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035064 methylated histone binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0043995 histone acetyltransferase activity (H4-K5 specific)
GO:0043996 histone acetyltransferase activity (H4-K8 specific)
GO:0046972 histone acetyltransferase activity (H4-K16 specific)
Biological Process
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034968 histone lysine methylation
GO:0043966 histone H3 acetylation
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043984 histone H4-K16 acetylation
GO:0045722 positive regulation of gluconeogenesis
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
GO:0071339 MLL1 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196363
View Gene Order
ENSBTAG00000047031
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_226917
HATs acetylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_244207
RMTs methylate histone arginines pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
circadianpathway
Circadian rhythm pathway
Cross-References
SwissProt P61965
TrEMBL
UniProt Splice Variant
Entrez Gene 140858
UniGene Mm.28265 Mm.473222
RefSeq NM_080848 XM_006497672
OMIM
CCDS CCDS15829
HPRD
IMGT
MGI ID MGI:2155884
MGI Symbol Wdr5
EMBL AF416510 AK075937 BC008547 BC016103 BC025801
GenPept AAH08547 AAH16103 AAH25801 AAL27006 BAC36067
RNA Seq Atlas 140858

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca