InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPC4

Summary

InnateDB Protein

IDBP-25294.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPC4

Protein Name

transient receptor potential cation channel, subfamily C, member 4

Synonyms

HTRP-4; HTRP4; TRP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000369027

InnateDB Gene

IDBG-25292 (TRPC4)

Protein Structure

UniProt Annotation

Function

Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion. {ECO:0000269PubMed:16144838, ECO:0000269PubMed:19996314}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor.

Disease Associations

Tissue Specificity

Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain. {ECO:0000269PubMed:19996314}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0015279	store-operated calcium channel activity
GO:0045296	cadherin binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007411	axon guidance
GO:0014051	gamma-aminobutyric acid secretion
GO:0034220	ion transmembrane transport
GO:0048709	oligodendrocyte differentiation
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005901	caveola
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030863	cortical cytoskeleton
GO:0034704	calcium channel complex
GO:0043234	protein complex
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR004729 Transient receptor potential channel
IPR005460 Transient receptor potential channel, canonical 4
IPR005821 Ion transport domain
IPR013555 Transient receptor ion channel domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF00520
PF08344
PF11929
PF12796

PRINTS

PR01415
PR01097
PR01645

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt