Version 5.4
Homo sapiens Gene: TRPC4
Summary
InnateDB Gene IDBG-25292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPC4
Gene Name transient receptor potential cation channel, subfamily C, member 4
Synonyms HTRP-4; HTRP4; TRP4
Species Homo sapiens
Ensembl Gene ENSG00000133107
Encoded Proteins
IDBP-25294
transient receptor potential cation channel, subfamily C, member 4
IDBP-25302
transient receptor potential cation channel, subfamily C, member 4
IDBP-25306
transient receptor potential cation channel, subfamily C, member 4
IDBP-25308
transient receptor potential cation channel, subfamily C, member 4
IDBP-25310
transient receptor potential cation channel, subfamily C, member 4
IDBP-25312
transient receptor potential cation channel, subfamily C, member 4
IDBP-365506
transient receptor potential cation channel, subfamily C, member 4
IDBP-586691
transient receptor potential cation channel, subfamily C, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:37636636-37870425
Strand Reverse strand
Band q13.3
Transcripts
ENST00000379705 ENSP00000369027
ENST00000379679 ENSP00000369001
ENST00000355779 ENSP00000348025
ENST00000358477 ENSP00000351264
ENST00000379673 ENSP00000368995
ENST00000338947 ENSP00000342580
ENST00000426868 ENSP00000410133
ENST00000488717 ENSP00000435969
ENST00000494529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0015279 store-operated calcium channel activity
GO:0045296 cadherin binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007411 axon guidance
GO:0014051 gamma-aminobutyric acid secretion
GO:0034220 ion transmembrane transport
GO:0048709 oligodendrocyte differentiation
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005911 cell-cell junction
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030863 cortical cytoskeleton
GO:0034704 calcium channel complex
GO:0043234 protein complex
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027748
View Gene Order
ENSBTAG00000009405
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_22228
Role of second messengers in netrin-1 signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
REACT_25300
Ion channel transport pathway
REACT_169333
TRP channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9UBN4
TrEMBL
UniProt Splice Variant
Entrez Gene 7223
UniGene Hs.262960
RefSeq NM_001135958 NM_001135955 NM_001135956 NM_001135957 NM_003306 NM_016179
HUGO HGNC:12336
OMIM 603651
CCDS CCDS45035 CCDS45036 CCDS45038 CCDS45039 CCDS9365
HPRD 09154
IMGT
EMBL AF063822 AF063823 AF063824 AF063825 AF175406 AF421358 AF421359 AF421360 AF421361 AF421362 AL138679 AL354802 BC104725 CH471075 U40983
GenPept AAC50630 AAD51736 AAF22927 AAF22928 AAF22929 AAF22930 AAI04726 AAL24549 AAL24550 AAL24551 AAL24552 AAL24553 CAH70109 CAH70110 CAH70111 CAH70112 CAH70114 CAI15556 CAI15557 CAI15558 CAI15560 CAI15561 EAX08595 EAX08596 EAX08597 EAX08598 EAX08600 EAX08601
RNA Seq Atlas 7223

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca