InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNASE7

Summary

InnateDB Protein

IDBP-2530.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNASE7

Protein Name

ribonuclease, RNase A family, 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000298690

InnateDB Gene

IDBG-2528 (RNASE7)

Protein Structure

UniProt Annotation

Function

Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. {ECO:0000269PubMed:12244054, ECO:0000269PubMed:12527768, ECO:0000269PubMed:17150966}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart. {ECO:0000269PubMed:12244054, ECO:0000269PubMed:12527768}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0003676	nucleic acid binding
GO:0004540	ribonuclease activity
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters
GO:0042834	peptidoglycan binding

Biological Process

GO:0009617	response to bacterium
GO:0019731	antibacterial humoral response
GO:0045087	innate immune response (InnateDB)
GO:0050829	defense response to Gram-negative bacterium
GO:0050830	defense response to Gram-positive bacterium
GO:0051673	membrane disruption in other organism
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic