Version 5.4
Mus musculus Protein: Ssh3
Summary
InnateDB Protein IDBP-253003.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ssh3
Protein Name slingshot homolog 3 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000109483
InnateDB Gene IDBG-129295 (Ssh3)
Protein Structure
UniProt Annotation
Function Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. {ECO:0000269PubMed:14531860}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:14531860}. Nucleus {ECO:0000269PubMed:14531860}.
Disease Associations
Tissue Specificity Expressed in brain, small intestine and testis. Also expressed at lower levels in heart, kidney, liver, spleen and thymus. {ECO:0000269PubMed:14531860}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0010591 regulation of lamellipodium assembly
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0050770 regulation of axonogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID MGI:2683546
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR014876 DEK, C-terminal
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00782
PF08766
PRINTS
PIRSF
SMART SM00195
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K330
PhosphoSite PhosphoSite-Q8K330
TrEMBL
UniProt Splice Variant
Entrez Gene 245857
UniGene
RefSeq XP_006531811
MGI ID
MGI Symbol Ssh3
OMIM
CCDS
HPRD
IMGT
EMBL AB099289 AK149880 BC028922
GenPept AAH28922 BAC97812 BAE29141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca