InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pja1

Summary

InnateDB Protein

IDBP-253137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pja1

Protein Name

praja1, RING-H2 motif containing

Synonyms

praja-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109423

InnateDB Gene

IDBG-215384 (Pja1)

Protein Structure

UniProt Annotation

Function

Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting. {ECO:0000269PubMed:10500182, ECO:0000269PubMed:12036302}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in brain, liver, kidney. Highest levels in brain where it is found in many regions including cortical and subcortical areas and in neurons of the amygdala. Weak expression also found in testis. Also expressed in developing embryo.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding