InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pja1

Summary

InnateDB Gene

IDBG-215384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pja1

Gene Name

praja1, RING-H2 motif containing

Synonyms

praja-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034403

Encoded Proteins

IDBP-253140

praja1, RING-H2 motif containing

IDBP-253135

praja1, RING-H2 motif containing

IDBP-253137

praja1, RING-H2 motif containing

IDBP-253139

praja1, RING-H2 motif containing

IDBP-621757

praja1, RING-H2 motif containing

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181191:
This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:99465734-99471273

Strand

Reverse strand

Band

Transcripts

ENSMUST00000036354	ENSMUSP00000109420
ENSMUST00000113797	ENSMUSP00000109428
ENSMUST00000113792	ENSMUSP00000109423
ENSMUST00000113790	ENSMUSP00000109421
ENSMUST00000167246	ENSMUSP00000132393

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process

Cellular Component

GO:0005737

cytoplasm

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000181191

View Gene Order

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

B1AXU4

UniProt Splice Variant

Entrez Gene

18744

UniGene

Mm.415536 Mm.8211

RefSeq

NM_001290556 XM_006527898 NM_001083110 NM_008853

OMIM

CCDS

CCDS41070 CCDS41071

HPRD

IMGT

MGI ID

MGI:1101765

MGI Symbol

Pja1

EMBL

AL831752 CH466564

GenPept

EDL14193

RNA Seq Atlas

18744