Version 5.4
Mus musculus Protein: Wdr34
Summary
InnateDB Protein IDBP-253336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wdr34
Protein Name WD repeat domain 34
Synonyms 3200002I06Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000109340
InnateDB Gene IDBG-155156 (Wdr34)
Protein Structure
UniProt Annotation
Function Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:24183451}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269PubMed:24183451}. Note=Concentrates around the centrioles and basal bodies also showing axonemal staining.
Disease Associations
Tissue Specificity Expressed in brain, thymus, heart, lung, liver, spleen, kidney, testis and intestine. {ECO:0000269PubMed:19521662}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005814 centriole
GO:0005930 axoneme
GO:0036064 ciliary basal body
Protein Structure and Domains
PDB ID MGI:1919070
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5U4F6
PhosphoSite PhosphoSite-Q5U4F6
TrEMBL A2BE91
UniProt Splice Variant
Entrez Gene 71820
UniGene Mm.88053
RefSeq NP_001008498
MGI ID
MGI Symbol Wdr34
OMIM
CCDS CCDS15865
HPRD
IMGT
EMBL AL928926 BC085113 BX005298 CH466542
GenPept AAH85113 EDL08430

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca