InnateDB Protein
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IDBP-25345.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IPO8
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Protein Name
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importin 8
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Synonyms
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RANBP8;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000256079
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InnateDB Gene
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IDBG-25343 (IPO8)
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Protein Structure
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Function |
Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19. {ECO:0000269PubMed:11682607, ECO:0000269PubMed:9214382}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
28
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001494
Importin-beta, N-terminal domain
IPR013713
Exportin/Importin, Cse1-like
IPR016024
Armadillo-type fold
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PFAM |
PF03810
PF08506
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PRINTS |
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PIRSF |
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SMART |
SM00913
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TIGRFAMs |
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Modification |
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SwissProt |
O15397
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PhosphoSite |
PhosphoSite-O15397
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TrEMBL |
F5H009
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UniProt Splice Variant |
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Entrez Gene |
10526
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UniGene |
Hs.629863
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RefSeq |
NP_006381
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HUGO |
HGNC:9853
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OMIM |
605600
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CCDS |
CCDS8719
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HPRD |
09282
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IMGT |
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EMBL |
AC012673
AC023426
AK302260
U77494
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GenPept |
AAB67052
BAH13659
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