Homo sapiens Gene: IPO8
Summary
InnateDB Gene IDBG-25343.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IPO8
Gene Name importin 8
Synonyms RANBP8
Species Homo sapiens
Ensembl Gene ENSG00000133704
Encoded Proteins
importin 8
importin 8
importin 8
importin 8
importin 8
importin 8
importin 8
importin 8
importin 8
importin 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:30628988-30695986
Strand Reverse strand
Band p11.21
Transcripts
ENST00000256079 ENSP00000256079
ENST00000358724 ENSP00000444050
ENST00000544829 ENSP00000444520
ENST00000535598 ENSP00000446232
ENST00000542464 ENSP00000439556
ENST00000535989 ENSP00000440979
ENST00000540979 ENSP00000443789
ENST00000543446 ENSP00000439413
ENST00000545077 ENSP00000446254
ENST00000538338
ENST00000611458 ENSP00000481026
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 25 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Transcriptional regulation by small RNAs pathway
Gene Expression pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.505136 Hs.629863
RefSeq NM_001190995 NM_006390
HUGO
OMIM
CCDS CCDS53773 CCDS8719
HPRD 09282
IMGT
EMBL
GenPept
RNA Seq Atlas