InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp2r4

Summary

InnateDB Protein

IDBP-253526.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp2r4

Protein Name

protein phosphatase 2A, regulatory subunit B (PR 53)

Synonyms

2610042B21Rik; C77440; N28142; PR53;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109233

InnateDB Gene

IDBG-156714 (Ppp2r4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005102	receptor binding
GO:0005524	ATP binding
GO:0008160	protein tyrosine phosphatase activator activity
GO:0008601	protein phosphatase type 2A regulator activity
GO:0016887	ATPase activity
GO:0019211	phosphatase activator activity
GO:0042803	protein homodimerization activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006200	ATP catabolic process
GO:0030472	mitotic spindle organization in nucleus
GO:0032515	negative regulation of phosphoprotein phosphatase activity
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0035307	positive regulation of protein dephosphorylation
GO:0035308	negative regulation of protein dephosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0034704	calcium channel complex

Protein Structure and Domains

PDB ID

MGI:1346006

InterPro

IPR004327 Phosphotyrosyl phosphatase activator, PTPA

PFAM

PF03095

PRINTS

PIRSF

PIRSF016325

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B7ZDE0

UniProt Splice Variant

Entrez Gene

110854

UniGene

Mm.275393

RefSeq

MGI ID

MGI Symbol

Ppp2r4

OMIM

CCDS

HPRD

IMGT

EMBL

AL954299

GenPept