Mus musculus Gene: Ppp2r4 | |||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-156714.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Ppp2r4 | ||||||||||||||||||||||||
Gene Name | protein phosphatase 2A, regulatory subunit B (PR 53) | ||||||||||||||||||||||||
Synonyms | 2610042B21Rik; C77440; N28142; PR53 | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000039515 | ||||||||||||||||||||||||
Encoded Proteins |
protein phosphatase 2A, regulatory subunit B (PR 53)
protein phosphatase 2A, regulatory subunit B (PR 53)
protein phosphatase 2A, regulatory subunit B (PR 53)
protein phosphatase 2A, regulatory subunit B (PR 53)
protein phosphatase 2A, regulatory subunit B (PR 53)
protein phosphatase 2A, regulatory subunit B (PR 53)
protein phosphatase 2A, regulatory subunit B (PR 53)
|
||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119383:
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B\'/PR61, and B\'\'/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B\' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 2:30416039-30447806 | ||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||
Band | B | ||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||||
Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||||
KEGG | |||||||||||||||||||||||||
INOH |
Insulin receptor signaling pathway
GPCR Dopamine D1like receptor signaling pathway pathway
|
||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH |
IL11 pathway
|
||||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||||
KEGG | |||||||||||||||||||||||||
INOH |
Insulin receptor signaling pathway
GPCR Dopamine D1like receptor signaling pathway pathway
|
||||||||||||||||||||||||
PID NCI |
Validated targets of C-MYC transcriptional repression
p53 pathway
|
||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
UniGene | Mm.275393 | ||||||||||||||||||||||||
RefSeq | NM_138748 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS15883 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||