InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Speg

Summary

InnateDB Protein

IDBP-253556.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Speg

Protein Name

SPEG complex locus

Synonyms

Apeg1; AW125581; BPEG; D1Bwg1450e; mKIAA1297; SPEGalpha; SPEGbeta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109217

InnateDB Gene

IDBG-170969 (Speg)

Protein Structure

UniProt Annotation

Function

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

Subcellular Localization

Isoform 3: Nucleus.

Disease Associations

Tissue Specificity

Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. {ECO:0000269PubMed:10973969, ECO:0000269PubMed:8663449}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006468	protein phosphorylation
GO:0055013	cardiac muscle cell development
GO:0060541	respiratory system development
GO:0072358	cardiovascular system development