InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fnbp1

Summary

InnateDB Protein

IDBP-253611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fnbp1

Protein Name

formin binding protein 1

Synonyms

1110057E06Rik; 2210010H06Rik; FBP1; Fbp17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109192

InnateDB Gene

IDBG-157485 (Fnbp1)

Protein Structure

UniProt Annotation

Function

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the actin cytoskeleton. May be required for the lysosomal retention of FASLG/FASL (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain and testis. {ECO:0000269PubMed:15252009}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0042802	identical protein binding

Biological Process

GO:0006897	endocytosis
GO:0007165	signal transduction

Cellular Component

GO:0005575	cellular_component
GO:0005764	lysosome
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0005938	cell cortex
GO:0016023	cytoplasmic membrane-bounded vesicle