InnateDB Protein
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IDBP-253624.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fnbp1
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Protein Name
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formin binding protein 1
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Synonyms
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1110057E06Rik; 2210010H06Rik; FBP1; Fbp17;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000109181
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InnateDB Gene
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IDBG-157485 (Fnbp1)
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Protein Structure
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Function |
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the actin cytoskeleton. May be required for the lysosomal retention of FASLG/FASL (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain and testis. {ECO:0000269PubMed:15252009}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
21 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:109606
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InterPro |
IPR001060
FCH domain
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PFAM |
PF00611
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PRINTS |
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PIRSF |
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SMART |
SM00055
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TIGRFAMs |
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Modification |
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SwissProt |
Q80TY0
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PhosphoSite |
PhosphoSite-Q80TY0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14269
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UniGene |
Mm.52297
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RefSeq |
NP_062279
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MGI ID |
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MGI Symbol |
Fnbp1
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OMIM |
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CCDS |
CCDS15894
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HPRD |
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IMGT |
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EMBL |
AK052652
AK122308
AK143512
AK157135
AK170497
AK172100
AL844546
BC003867
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GenPept |
AAH03867
BAC35082
BAC65590
BAE25408
BAE33974
BAE41836
BAE42825
CAM18436
CAM18442
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