Version 5.4
Mus musculus Protein: Vegfa
Summary
InnateDB Protein IDBP-253705.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Vegfa
Protein Name vascular endothelial growth factor A
Synonyms Vegf; Vpf;
Species Mus musculus
Ensembl Protein ENSMUSP00000109147
InnateDB Gene IDBG-185847 (Vegfa)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 6 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0043183 vascular endothelial growth factor receptor 1 binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0046982 protein heterodimerization activity
GO:0050840 extracellular matrix binding
Biological Process
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001568 blood vessel development
GO:0001569 patterning of blood vessels
GO:0001701 in utero embryonic development
GO:0001822 kidney development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001944 vasculature development
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003007 heart morphogenesis
GO:0007498 mesoderm development
GO:0007595 lactation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0016477 cell migration
GO:0030324 lung development
GO:0030855 epithelial cell differentiation
GO:0031077 post-embryonic camera-type eye development
GO:0040007 growth
GO:0042462 eye photoreceptor cell development
GO:0043066 negative regulation of apoptotic process
GO:0043117 positive regulation of vascular permeability
GO:0043129 surfactant homeostasis
GO:0045087 innate immune response (InnateDB)
GO:0045766 positive regulation of angiogenesis
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048469 cell maturation
GO:0048514 blood vessel morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048739 cardiac muscle fiber development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048844 artery morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051781 positive regulation of cell division
GO:0060319 primitive erythrocyte differentiation
GO:0060426 lung vasculature development
GO:0060749 mammary gland alveolus development
GO:0071456 cellular response to hypoxia
GO:0071542 dopaminergic neuron differentiation
GO:1901492 positive regulation of lymphangiogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:103178
InterPro IPR000072 PDGF/VEGF domain
IPR029034 Cystine-knot cytokine
PFAM PF00341
PRINTS
PIRSF
SMART SM00141
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q5UD54
UniProt Splice Variant
Entrez Gene 22339
UniGene Mm.473100
RefSeq
MGI ID
MGI Symbol Vegfa
OMIM
CCDS
HPRD
IMGT
EMBL AC127690 AY756068 EF028705
GenPept AAV32504 ABK27265

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca