InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOC2A

Summary

InnateDB Protein

IDBP-25374.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOC2A

Protein Name

double C2-like domains, alpha

Synonyms

Doc2;

Species

Homo sapiens

Ensembl Protein

ENSP00000340017

InnateDB Gene

IDBG-25372 (DOC2A)

Protein Structure

UniProt Annotation

Function

Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269PubMed:18354201, ECO:0000269PubMed:9736751, ECO:0000269PubMed:9804756}.

Subcellular Localization

Lysosome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles.

Disease Associations

Tissue Specificity

Predominantly expressed in brain. Also expressed in testis. {ECO:0000269PubMed:7826360, ECO:0000269PubMed:8554557}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding

Biological Process

GO:0007268	synaptic transmission
GO:0007399	nervous system development
GO:0016079	synaptic vesicle exocytosis
GO:0017158	regulation of calcium ion-dependent exocytosis