Version 5.4
Homo sapiens Gene: DOC2A
Summary
InnateDB Gene IDBG-25372.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOC2A
Gene Name double C2-like domains, alpha
Synonyms Doc2
Species Homo sapiens
Ensembl Gene ENSG00000149927
Encoded Proteins
IDBP-25374
double C2-like domains, alpha
IDBP-753857
IDBP-751326
IDBP-749054
IDBP-753522
IDBP-752640
IDBP-745100
IDBP-752695
IDBP-754168
IDBP-751166
IDBP-808773
double C2-like domains, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. [provided by RefSeq, Jul 2008]
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30005509-30023270
Strand Reverse strand
Band p11.2
Transcripts
ENST00000350119 ENSP00000340017
ENST00000566310 ENSP00000454857
ENST00000563378 ENSP00000456704
ENST00000567332 ENSP00000454827
ENST00000572637
ENST00000565273 ENSP00000457184
ENST00000564357
ENST00000564075
ENST00000570194
ENST00000566456
ENST00000574405 ENSP00000460622
ENST00000564233
ENST00000564979 ENSP00000455624
ENST00000563125 ENSP00000457454
ENST00000561671 ENSP00000458670
ENST00000567824
ENST00000564944 ENSP00000455196
ENST00000616445 ENSP00000482870
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
Biological Process
GO:0007268 synaptic transmission
GO:0007399 nervous system development
GO:0016079 synaptic vesicle exocytosis
GO:0017158 regulation of calcium ion-dependent exocytosis
Cellular Component
GO:0005764 lysosome
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052301
View Gene Order
ENSBTAG00000005031
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.355281 Hs.733294
RefSeq NM_001282062 NM_001282063 NM_001282068 NM_003586 XM_005255635 XM_006721097 XM_006721098
HUGO
OMIM
CCDS CCDS10666
HPRD 05195
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca