InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccl20

Summary

InnateDB Protein

IDBP-253878.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccl20

Protein Name

chemokine (C-C motif) ligand 20

Synonyms

CKb4; exodus-1; LARC; MIP-3[a]; MIP-3A; MIP3A; Scya20; ST38;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109064

InnateDB Gene

IDBG-174322 (Ccl20)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Prominently expressed in the small intestine, colon and appendix. Also found in thymus, spleen, lymph node and lung. The long form might be dominant in intestinal, and the short form in lymphoid tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0042060	wound healing
GO:0042466	chemokinesis
GO:0050726	positive regulation of interleukin-1 alpha biosynthetic process
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0060326	cell chemotaxis
GO:0071222	cellular response to lipopolysaccharide
GO:0071223	cellular response to lipoteichoic acid
GO:0071310	cellular response to organic substance
GO:2000406	positive regulation of T cell migration