InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dach2

Summary

InnateDB Protein

IDBP-254005.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dach2

Protein Name

dachshund 2 (Drosophila)

Synonyms

9430028N04Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109007

InnateDB Gene

IDBG-168970 (Dach2)

Protein Structure

UniProt Annotation

Function

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression. Probably binds to DNA via its DACHbox-N domain. {ECO:0000269PubMed:12112464, ECO:0000269PubMed:12130660}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in embryo, and at lower levels in the newborn. {ECO:0000269PubMed:11287190}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0046545	development of primary female sexual characteristics