Version 5.4
Homo sapiens Protein: DLEC1
Summary
InnateDB Protein IDBP-25407.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLEC1
Protein Name deleted in lung and esophageal cancer 1
Synonyms CFAP81; DLC1; F56;
Species Homo sapiens
Ensembl Protein ENSP00000315914
InnateDB Gene IDBG-25403 (DLEC1)
Protein Structure
UniProt Annotation
Function May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269PubMed:10213508}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10213508}.
Disease Associations Note=DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of different cancers, including esophageal (ESCR), renal and lung cancers (LNCR).Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis. Note=The disease is caused by mutations affecting the gene represented in this entry. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of lung cancer.Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269PubMed:10213508}. Note=The disease is caused by mutations affecting the gene represented in this entry. DLEC1 silencing due to promoter methylation and aberrant transcription are implicated in the development of esophageal cancer.
Tissue Specificity Expressed in all tissues examined. Expression is highest in prostate and testis. {ECO:0000269PubMed:10213508}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008962 PapD-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y238
PhosphoSite PhosphoSite-Q9Y238
TrEMBL
UniProt Splice Variant
Entrez Gene 9940
UniGene Hs.714499
RefSeq NP_031363
HUGO HGNC:2899
OMIM 604050
CCDS
HPRD 07234
IMGT
EMBL AB020522 AB026898 AC144536 AL137282 AL137706 AP006309
GenPept BAA77247 BAA77624 CAB70676 CAB70884

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca