InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sytl4

Summary

InnateDB Protein

IDBP-254168.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sytl4

Protein Name

synaptotagmin-like 4

Synonyms

Gph; Slp4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108922

InnateDB Gene

IDBG-170513 (Sytl4)

Protein Structure

UniProt Annotation

Function

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner. {ECO:0000269PubMed:12590134}.

Subcellular Localization

Membrane {ECO:0000269PubMed:10497219}; Peripheral membrane protein {ECO:0000269PubMed:10497219}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269PubMed:10497219}; Peripheral membrane protein {ECO:0000269PubMed:10497219}. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles.

Disease Associations

Tissue Specificity

Detected in the pancreatic islet, in particular in insulin-positive beta cells, and in pituitary. {ECO:0000269PubMed:10497219}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008270	zinc ion binding
GO:0017137	Rab GTPase binding
GO:0042043	neurexin family protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0045921	positive regulation of exocytosis
GO:0046676	negative regulation of insulin secretion
GO:0050714	positive regulation of protein secretion
GO:0071985	multivesicular body sorting pathway

Cellular Component

GO:0005634	nucleus
GO:0005768	endosome
GO:0005813	centrosome
GO:0019898	extrinsic component of membrane
GO:0030141	secretory granule
GO:0030658	transport vesicle membrane