Version 5.4
Mus musculus Protein: Frs3
Summary
InnateDB Protein IDBP-254183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Frs3
Protein Name fibroblast growth factor receptor substrate 3
Synonyms 4930417B13Rik; AI449674; Frs2beta; Snt2;
Species Mus musculus
Ensembl Protein ENSMUSP00000108921
InnateDB Gene IDBG-189460 (Frs3)
Protein Structure
UniProt Annotation
Function Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.
Subcellular Localization Membrane; Lipid-anchor.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0008543 fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2135965
InterPro IPR002404 Insulin receptor substrate-1, PTB
PFAM PF02174
PRINTS PR00628
PIRSF
SMART SM00310
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91WJ0
PhosphoSite PhosphoSite-Q91WJ0
TrEMBL D3Z2C8
UniProt Splice Variant
Entrez Gene 107971
UniGene
RefSeq NP_659188
MGI ID
MGI Symbol Frs3
OMIM
CCDS CCDS28854
HPRD
IMGT
EMBL AC124830 AC139214 AF456480 BC014819
GenPept AAH14819 AAO15529

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca