Version 5.4
Mus musculus Gene: Frs3
Summary
InnateDB Gene IDBG-189460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Frs3
Gene Name fibroblast growth factor receptor substrate 3
Synonyms 4930417B13Rik; AI449674; Frs2beta; Snt2
Species Mus musculus
Ensembl Gene ENSMUSG00000023266
Encoded Proteins
IDBP-254183
fibroblast growth factor receptor substrate 3
IDBP-534622
fibroblast growth factor receptor substrate 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137218:
The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. [provided by RefSeq, Jul 2008]
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47689030-47704286
Strand Forward strand
Band C
Transcripts
ENSMUST00000113296 ENSMUSP00000108921
ENSMUST00000156118 ENSMUSP00000121698
ENSMUST00000128734
ENSMUST00000139405
ENSMUST00000138316
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0008543 fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137218
View Gene Order
ENSBTAG00000009861
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_234357
FRS2-mediated cascade pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
KEGG
INOH
INOH website
FGF8 signaling (Mouse) pathway
INOH website
FGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_21247
FRS2-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
FGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_144939 XM_006523468 XM_006523469 XM_006523470
OMIM
CCDS CCDS28854
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca