InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cstf2

Summary

InnateDB Protein

IDBP-254197.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cstf2

Protein Name

cleavage stimulation factor, 3' pre-RNA subunit 2

Synonyms

C630034J23Rik; Cstf64;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108911

InnateDB Gene

IDBG-170595 (Cstf2)

Protein Structure

UniProt Annotation

Function

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14681198}. Note=Localized with DDX1 in cleavage bodies. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in most somatic cell types (at protein level). Highly expressed in testis, except in meiotic spermatocytes. {ECO:0000269PubMed:11369601, ECO:0000269PubMed:14681198}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding

Biological Process

GO:0006397

mRNA processing

Cellular Component

GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
GO:0071920	cleavage body

Protein Structure and Domains

PDB ID

MGI:1343054

InterPro

IPR000504 RNA recognition motif domain

PFAM

PF00076

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BIQ5

PhosphoSite

PhosphoSite-Q8BIQ5

TrEMBL

UniProt Splice Variant

Entrez Gene

108062

UniGene

Mm.67938

RefSeq

NP_001277328

MGI ID

MGI Symbol

Cstf2

OMIM

CCDS

HPRD

IMGT

EMBL

AF317552 AK032817 AK088260 AL671915 BC036719

GenPept

AAG31814 AAH36719 BAC28037 BAC40243 CAM16728 CAM16729