Version 5.4
Mus musculus Gene: Cstf2
Summary
InnateDB Gene IDBG-170595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cstf2
Gene Name cleavage stimulation factor, 3' pre-RNA subunit 2
Synonyms C630034J23Rik; Cstf64
Species Mus musculus
Ensembl Gene ENSMUSG00000031256
Encoded Proteins
IDBP-170597
cleavage stimulation factor, 3' pre-RNA subunit 2
IDBP-254195
cleavage stimulation factor, 3' pre-RNA subunit 2
IDBP-254197
cleavage stimulation factor, 3' pre-RNA subunit 2
IDBP-540488
cleavage stimulation factor, 3' pre-RNA subunit 2
IDBP-537796
cleavage stimulation factor, 3' pre-RNA subunit 2
IDBP-532924
cleavage stimulation factor, 3' pre-RNA subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101811:
This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]
This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3\' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3\'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:134059187-134086819
Strand Forward strand
Band E3
Transcripts
ENSMUST00000033609 ENSMUSP00000033609
ENSMUST00000113287 ENSMUSP00000108912
ENSMUST00000113286 ENSMUSP00000108911
ENSMUST00000148080
ENSMUST00000149658
ENSMUST00000144483 ENSMUSP00000114837
ENSMUST00000156778 ENSMUSP00000117592
ENSMUST00000136510 ENSMUSP00000117806
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:0071920 cleavage body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101811
View Gene Order
ENSBTAG00000003547
Not yet available
Pathways
NETPATH
REACTOME
REACT_240247
mRNA 3'-end processing pathway
REACT_249110
mRNA Splicing pathway
REACT_248407
Processing of Capped Intronless Pre-mRNA pathway
REACT_232123
Processing of Intronless Pre-mRNAs pathway
REACT_257346
RNA Polymerase II Transcription Termination pathway
REACT_253727
Cleavage of Growing Transcript in the Termination Region pathway
REACT_233572
Gene Expression pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
mmu03015
mRNA surveillance pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1096
Processing of Intronless Pre-mRNAs pathway
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1768
Processing of Capped Intronless Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_209718
RNA Polymerase II Transcription pathway
REACT_224643
Cleavage of Growing Transcript in the Termination Region pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_204974
Processing of Capped Intronless Pre-mRNA pathway
REACT_203211
mRNA 3'-end processing pathway
REACT_224606
RNA Polymerase II Transcription Termination pathway
REACT_226022
Gene Expression pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_225642
Processing of Intronless Pre-mRNAs pathway
KEGG
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.413319 Mm.67938
RefSeq NM_001290398 NM_001290399 NM_133196 XM_006528482
OMIM
CCDS CCDS30389 CCDS72430
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca