Version 5.4
Mus musculus Protein: Foxp4
Summary
InnateDB Protein IDBP-254235.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Foxp4
Protein Name forkhead box P4
Synonyms 1200010K03Rik; 2310007G05Rik; mFKHLA;
Species Mus musculus
Ensembl Protein ENSMUSP00000108890
InnateDB Gene IDBG-189596 (Foxp4)
Protein Structure
UniProt Annotation
Function Transcriptional repressor that represses lung-specific expression. {ECO:0000269PubMed:14701752}.
Subcellular Localization Nucleus {ECO:0000255, ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in the adult heart, brain, spleen lung, liver, kidney and testes. {ECO:0000269PubMed:12818433, ECO:0000269PubMed:14516685}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007507 heart development
GO:0048617 embryonic foregut morphogenesis
GO:0061140 lung secretory cell differentiation
GO:1901249 regulation of lung goblet cell differentiation
GO:1901250 negative regulation of lung goblet cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1921373
InterPro IPR001766 Transcription factor, fork head
PFAM PF00250
PRINTS PR00053
PIRSF
SMART SM00339
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DBY0
PhosphoSite PhosphoSite-Q9DBY0
TrEMBL
UniProt Splice Variant
Entrez Gene 74123
UniGene
RefSeq NP_083043
MGI ID
MGI Symbol Foxp4
OMIM
CCDS CCDS50135
HPRD
IMGT
EMBL AB052766 AK004693 AY135029 BC043702 BC052407 BC057110
GenPept AAH43702 AAH52407 AAH57110 AAN08624 BAB23479 BAC53799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca