InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Foxp4

Summary

InnateDB Gene

IDBG-189596.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxp4

Gene Name

forkhead box P4

Synonyms

1200010K03Rik; 2310007G05Rik; mFKHLA

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023991

Encoded Proteins

IDBP-189600

forkhead box P4

IDBP-254235

forkhead box P4

IDBP-254237

forkhead box P4

IDBP-254239

forkhead box P4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137166:
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:47867133-47924645

Strand

Reverse strand

Band

Transcripts

ENSMUST00000097311	ENSMUSP00000094916
ENSMUST00000113265	ENSMUSP00000108890
ENSMUST00000113263	ENSMUSP00000108888
ENSMUST00000113262	ENSMUSP00000108887
ENSMUST00000136314
ENSMUST00000154108
ENSMUST00000137039
ENSMUST00000153752

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007507	heart development
GO:0048617	embryonic foregut morphogenesis
GO:0061140	lung secretory cell differentiation
GO:1901249	regulation of lung goblet cell differentiation
GO:1901250	negative regulation of lung goblet cell differentiation

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000137166

View Gene Order

ENSBTAG00000014211

Not yet available

Cross-References

SwissProt

Q9DBY0

TrEMBL

UniProt Splice Variant

Entrez Gene

74123

UniGene

RefSeq

NM_001110824 XM_006525016 XM_006525017 NM_001110825 NM_028767

OMIM

CCDS

CCDS50137 CCDS50135 CCDS50136

HPRD

IMGT

MGI ID

MGI:1921373

MGI Symbol

Foxp4

EMBL

AB052766 AK004693 AY135029 BC043702 BC052407 BC057110

GenPept

AAH43702 AAH52407 AAH57110 AAN08624 BAB23479 BAC53799

RNA Seq Atlas

74123