InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sh2d3c

Summary

InnateDB Protein

IDBP-254287.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sh2d3c

Protein Name

SH2 domain containing 3C

Synonyms

Chat; Nsp3; Shep1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108868

InnateDB Gene

IDBG-161162 (Sh2d3c)

Protein Structure

UniProt Annotation

Function

Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10692442}. Membrane {ECO:0000269PubMed:10692442}; Peripheral membrane protein {ECO:0000269PubMed:10692442}. Note=Associated with the membrane when EGF-stimulated. Found at ruffling membranes.

Disease Associations

Tissue Specificity

Isoform 2 is ubiquitously expressed. Isoform 1 is expressed in hematopoietic cells from spleen, lymph node and thymus. {ECO:0000269PubMed:10542222, ECO:0000269PubMed:10692442, ECO:0000269PubMed:12486027}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0043087	regulation of GTPase activity